腹腔镜术后联合GnRH-α治疗子宫内膜异位症伴不孕患者的妊娠结局分析

中文关键词:  子宫内膜异位症 腹腔镜 促性腺激素释放激素激动剂 不孕 妊娠结局

中文摘要:

      目的 探讨子宫内膜异位症伴不孕患者腹腔镜手术联合促性腺激素释放激素激动剂（GnRH-α）治疗后的自然妊娠率及妊娠结局。方法 将子宫内膜异位症伴不孕患者256例，随机分为单纯腹腔镜手术组127例（A组），腹腔镜联合GnRH-α组129例（B组），术后电话随访12~28个月，对两组患者术后试孕6个月、12个月的累计自然妊娠率及自然流产、宫外孕、早产、足月活产率等妊娠结局进行分析。结果 最终纳入患者229例。A、B两组患者术后试孕12个月的累积妊娠率分别是52.7％(58/110)与69.7％(83/119)，差异有统计学意义(P<0.05)。A、B两组患者之间自然流产率、宫外孕率、早产率、足月活产率差异无统计学意义(P>0.05)。结论 腹腔镜术后联合GnRH-α治疗较单纯腹腔镜手术治疗对提高子宫内膜异位症不孕患者的妊娠率有更好的效果。

英文摘要:

      【Abstract】 Objective To develop a new method for simultaneous determination of eight organochlorine pesticides (OCPs) in water samples using solidification floating organic drop liquid-phase microextraction (SFO-LPME) combined with gas chromatography-electronic capture detector (GC-ECD). Methods The experimental conditions of SFO-LPME were determined with n-Hexadecane as extractant, water samples adjusted to pH 6.0, inonic strength increased by adding 15.0 g/100 mL NaCl. The OCPs were extracted at 55℃ for 10 min and determined with GC-ECD. Results A good linearity (correlation coefficients ≥0.996) was obtained for eight target compounds from 5 ng/L to 100 ng/L. The method detection limits ranged from 0.24 ng/L to 0.78 ng/L. Satisfactory results were achieved with samples of river water, piped water and farmland water, with an average recovery of 76.0%-106.0% and RSD of 3.24%-11.60%. Conclusion The proposed method is rapid, simple and sensitive. It is suitable for batch analyses of eight organic chlorine pesticides in water samples.