c-myb、Bax蛋白在子宫内膜癌中的表达及意义

Expression and Clinical Significances of c-myb and Bax Proteins in Endometrial Carcinoma

中文关键词:  c-myb Bax 子宫内膜癌

英文关键词:c-myb Bax Endometrial carcinoma

中文摘要:

      目的 探讨c-myb、Bax蛋白在子宫内膜癌中的表达和意义。方法 应用免疫组化SP法和TUNEL技术对68例子宫内膜样腺癌组织和42例正常子宫内膜组织中c-myb、Bax蛋白表达和细胞凋亡指数进行检测，结合临床病理指标进行分析。结果 c-myb、Bax在子宫内膜癌组织中的阳性表达率高于正常子宫内膜组织（P<0.05 ）。c-myb、Bax在分化程度越低的子宫内膜癌组织中的表达越高，在Ⅲ、Ⅳ期子宫内膜癌中的表达高于Ⅰ、Ⅱ期，差异有统计学意义（P<0.05）。子宫内膜癌组织的细胞凋亡指数高于正常子宫内膜组织，且子宫内膜癌细胞分化程度越低，细胞凋亡指数越高。Bax表达与子宫内膜癌细胞凋亡指数呈正相关（r=0.529, P<0.05），而c-myb表达与子宫内膜癌凋亡指数无相关性（P>0.05）。结论 子宫内膜癌中存在c-myb、Bax蛋白的高表达，c-myb参与肿瘤细胞的增殖分化调节，Bax调节肿瘤细胞凋亡，两者可作为判断子宫内膜癌恶性行为和预后的指标。

英文摘要:

      Objective To study the expressions of c-myb and Bax proteins and their relationships with clinic-pathological characteristics in endometrial carcinoma. Methods The expressions of c-myb and Bax protein were detected by immunohistochemistry in 42 normal endometrial tissues and 68 endometrial carcinoma tissues. Apoptosis index was detected by TUNEL technique. Results The positive expression rates of c-myb and Bax in endometrial carcinoma were significantly higher than those in normal endometrial tissues (P<0.05). The expressions of c-myb and Bax in low differentiated endometrial carcinoma were higher than those in high and middle differentiated endometrial carcinoma (P<0.05). The expressions of c-myb and Bax in stage Ⅲ and stage Ⅳ endometrial carcinoma were higher than those in stageⅠand stgeⅡ endometrial carcinoma (P<0.05). Apoptosis index in endometrial carcinoma was higher than that in normal endometrial carcinoma.The poorer the cellular differentiation was, the higher the apoptosis index was. There was positive correlation between the expression of Bax and apoptosis index (P<0.05), but no correlation between the expression of c-myb and apoptosis index (P>0.05). Conclusion Endometrial carcinoma has high expression of c-myb and Bax, and the expression status of both c-myb and Bax may be related to the malignant degree and prognosis of endometrial carcinoma.