子痫前期发病机制的研究现状及展望

Research Status of the Pathogenesis of Pre-eclampsia

中文关键词:  子痫前期 发病机制 胎盘 滋养细胞 遗传学

英文关键词:Preeclampsia Pathogenesis Placenta Trophoblastic cell Genetics

中文摘要:

      子痫前期是一种产科严重并发症，不仅影响孕产妇健康，还可影响后代远期预后，其发病机制至今不清，因此，对子痫前期发病机制的研究一直是产科领域的热点。目前子痫前期发病机制学说众多，但各有长短，本专题主要从可能与子痫前期发病有关的遗传、表观遗传及部分基因等的表达变化等方面探讨了子痫前期的发病机理。希望通过对众多观点的总结，整合相关资源，更新研究理念和丰富研究手段来取得子痫前期发病机理研究的新的突破。

英文摘要:

      Pre-eclampsia is a serious obstetric complication, not only affect maternal health, but also affect the long-term prognosis of offspring generation. Even though various theories on the pathogenesis of pre-eclampsia have been proposed in recent decades, it remains unclear due to the disadvantages in these theories. Therefore, the pathogenesis of pre-eclampsia keeps attracting a lot of research efforts in the field of obstetrics. In order to find the new break through points in the study of pre-eclampsia pathogenesis (pre-eclampsia related to genetic, epigenetic and expression changes of some genes), it is necessary to illustrate and understand the research status in this field, with integrating the related resources, updating the new progress, ideas and extensive research means.