钒作业工人的氧化应激水平研究

Oxidative Stress Level of Vanadium-exposed Workers

中文关键词:  结直肠腺瘤 结直肠癌 microRNA

英文关键词:Vanadium compound Oxidative stress

中文摘要:

      目的 评价钒暴露作业工人外周血氧化应激水平，为研究钒对神经系统的影响机制提供人群资料。方法 采用整群抽样的方法纳入86例接钒工人，65例对照工人。自制问卷收集人口学基本信息及职业暴露资料，试剂盒法检测目标人群外周血血清样本中的氧化应激水平〔超氧化物歧化酶（SOD），丙二醛（MDA），诱导型一氧化氮合酶（iNOS）〕。比较接钒工人和对照工人血清氧化应激水平的差异。 结果 接钒工人血清中MDA含量高于对照工人（ P<0.05），总超氧化物歧化酶（T-SOD）活性低于对照工人（ P<0.05）, 其中锰超氧化物歧化酶（Mn-SOD）活性降低明显（ P<0.05），而铜锌超氧化物歧化酶（CuZn-SOD）活性无明显变化（ P>0.05）。接钒工人和未接钒工人血清中的iNOS活性比较接近，差异无统计学意义（ P>0.05）。结论 钒暴露可能会影响作业工人的脂质过氧化，显著降低机体的抗氧化水平。目前尚不能确定钒与活性氮损伤之间的关系。

英文摘要:

      Objective To determine the relationship between lesion locations and quality of life (QOL) in patients with ischemic stroke. Methods The QOL of 456 stroke survivors was assessed two years after the occurrence of stroke. The EQ-5D was used for measuring QOL. Lesion locations of the patients were identified with CT, MRI and clinical features. Risk factors associated with QOL were identified using a multi-level model. Results Among the 456 stroke survivors, 61.62% (3/5) had ACI lesions, and more than half of ACI occurred in the subcortex. The number of stroke survivors with left and right hemisphere lesions was almost equal. Different QOL was found between stroke survivors with a right-side brain lesion and those with non-brain lesions ( P＜0.001). Significant differences in QOL were also found between those with a subcortex of anterior circulation lesion and others ( P＜0.044). Conclusion Lesion locations are associated with QOL. Future studies should pay attention to lesion locations classified by vascular territory and brain anatomical structures and size of lesions.