急性主动脉夹层患者血清儿茶酚胺质量浓度与氧合指数的 相关性研究

中文关键词:  急性主动脉夹层 儿茶酚胺 氧和指数 内毒素

英文关键词:Acute aortic dissection Catecholamines Oxygenation index Endotoxin

中文摘要:

      目的 探索急性主动脉夹层（acute aortic dissection，AAD）患者是否存在血清儿茶酚胺质量浓度的升高，以及患者血清儿茶酚胺质量浓度与氧合指数（oxygenation index，OI）的关系。HTH]方法 2013年4~12月期间，纳入3组患者（A组38例AAD患者、B组28例升主动脉瘤患者、C组22例心绞痛患者）为研究对象，收集所有患者一般临床资料，测定OI并采集血液标本测定肾上腺素（adrenaline，AD）、去甲肾上腺素（noradrenaline，NA）、内毒素（endotoxin，ET）的血清质量浓度。通过对3组患者上述指标的对比分析，观察AAD患者血清儿茶酚胺质量浓度是否升高；采用直线相关分析AAD患者血清儿茶酚胺质量浓度与ET质量浓度以及OI的关系。HTH]结果 3组患者一般临床资料差异无统计学意义。A组患者血清AD、NA、ET质量浓度均高于B组和C组（ P<0.001),OI低于B组和C组（ P<0.001)。采用直线相关分析发现AAD患者血清AD及NA质量浓度均与ET质量浓度存在正相关性，而与OI呈负相关性。结论 血清儿茶酚胺浓度的升高可能与AAD患者急性肺损伤有关。

英文摘要:

      Objective To explore whether the serum concentration of adrenaline (AD) and noradrenaline (NA) elevate and its correlation with oxygenation index (OI) in the patients of acute aortic dissection (AAD). Methods From April 2013 to December 2013, clinical data were collected from three groups of patients (38 cases of AAD in Group A, 28 cases of ascending aortic aneurysm in Group B, and 22 cases of angina in Group C). All patients received the measurement of serum concentrations of AD, NA and endotoxin (ET). Linear correlation was used to analyze the relationships between catecholamines (including AD and NA), ET and OI. Results The baseline of the three groups showed no significant difference. The serum concentrations of AD, NA and ET in Group A were higher than those in Group B and Group C ( P<0.01), white OI was lower than that in Group B and Group C ( P<0.001). In the patients with AAD, the serum concentrations of AD and NA were positively correlated with ET, while both were negatively correlated with OI. Conclusion Higher serum concentrations of AD and NA correlated with more severe acute lung injury in AAD patients.