姜黄素乙醇脂质体大鼠体内药代动力学研究

Pharmacokinetics of Curcumin Ethosomes in Rats in vitro

中文关键词:  【关键词】 姜黄素 乙醇脂质体 药代动力学 生物利用度 生物等效性

英文关键词:【Key words】 Curcumin Ethosomes Pharmacokinetics Bioavailability Bioequivalence

中文摘要:

      【摘要】 目的 考察大鼠体内姜黄素乙醇脂质体的药动学特点。方法 大鼠灌胃给药，高效液相色谱法测定各血药浓度，采用DAS 2.1.1软件处理并分析药动学数据。结果 在非室模型分析中，经计算姜黄素乙醇脂质体的0~72 h曲线下面积〔AUC （0-72 h）〕为游离姜黄素的1.6倍，其峰浓度C max为游离姜黄素的1.5倍，姜黄素乙醇脂质体的相对生物利用度为152.2%，姜黄素乙醇脂质体的AUC （0-72 h）的90%可置信区间为102.2%~128.5%，不在生物等效性标准区间内。在室模型分析中，姜黄素乙醇脂质体的AUC （0-72 h）为游离姜黄素的1.4倍，姜黄素乙醇脂质体的相对生物利用度为128.2%。结论 姜黄素乙醇脂质体可提高口服生物利用度，且与游离姜黄素生物不等效。

英文摘要:

      【Abstract】 Objective To study the oral phamacokinetics of curcumin ethosomes in rats. Methods Pharmacokinetics parameters were detected by DAS 2.1.1 software analysis through data of blood concentrations harvested from HPLC after oral administration of curcumin ethosomes in rats. Results Analyzed by non-compartmental method, the area under concentration-time curve from 0 to last time 〔AUC _{(0-72h)〕 of curcumin ethosomes was 1.6 times larger than that of free curcumin, the peak concentration (C max}) of curcumin ethosomes was 1.5 times higher than that of free curcumin, the relative bioavailability of curcumin ethosomes was 152.2%. The 90% confidential interval of AUC _{(0-72 h)}was 102.2%-128.5%, which was not in standard interval of bioequialence. Analyzed by compartmental method, the AUC _{(0-72 h)}of curcumin ethosomes was 1.4 times larger than that of free curcumin and the relative bioavailability of curcumin ethosomes was 128.2%. Conclusion The curcumin ethosomes can enhance bioavailability, which has a bioinequivalence with free curcumin.